An entry in Universal's six-picture "Inner Sanctum" series stars Chaney as a chemist who is upset with his boss's (Naish's) business practices. Naish sends the chemist to South America in order to continue some experiments, but, while Chaney is away, he steals a valuable formula and
Chaney's wife. Tired of being in the jungle, Chaney returns home and decapitates Naish. The story is told in flashback as Chaney is trying to convince his attorney friend to defend him.