For a movie all about pharmaceuticals that alter the body’s chemistry, Ed Zwick’s romantic comedy Love and Other Drugs
succeeds thanks to good old-fashioned onscreen chemistry between Jake Gyllenhaal and Anne Hathaway.
As preternaturally charming and ever-horny salesman Jamie Randall, Gyllenhaal manages to be as charming and roguish as George Clooney at his best. The movie’s opening-credit sequence swiftly establishes his character -- while flirting with every woman who walks into his stereo store, and selling lots of product in the process, Jamie seduces a co-worker who jumps his bones in the back of the store. When they are discovered in the act by...