Duff is a federal narcotics agent who springs Duryea from Alcatraz to help in smashing a ring of dope dealers. The trail takes them to San Francisco, Vancouver, Tucson, and Mexico, before the finale back in Tuscon. Winters is the girl friend of smuggler Kelley, who jilts her guy for Duff.
Gang member Curtis is killed by Duryea when he attempts to knock off Duff. Winters tips off the duo about a big deal and the agents swoop in at the climax. It's a standard police drama, though there are some exciting moments. Castle's direction keeps things moving briskly.