In this live action comedy with talking dogs, high-powered Hollywood agent Viv (Jamie Lee Curtis) entrusts her beloved chihuahua, Chloe (voice of Drew Barrymore) to her niece (Piper Perabo), who promply loses the pampered pooch in Mexico. Fortunately, Chloe has a secret beau named Papi (voice of George Lopez), a tough, street-smart chihuahua from the wrong side of the freeway, who'll stop at nothing to rescue his uptown girl.