Daniel Radcliffe

Harry Potter and the Half-Blood Prince took in a spellbinding $79.5 million over the weekend and $159.7 million over its five-day debut. (Internationally, the wizardly Warner Bros. film also dominated the box office with a $396.7 million total take — the strongest start ever for a Harry Potter film.)

Exit polls showed loyal fans are standing by the franchise as they are maturing, with 60 percent of audiences comprised of moviegoers over the age of 18 — much greater than the last five films. Half-Blood earned $20 million more than 2007's Harry Potter and the Order of the Phoenix, the last movie in the franchise.

Check out photos from Harry Potter and the Half-Blood Prince

In Muggle film news over the weekend, the Fox Searchlight romantic comedy 500 Days of Summer, starring Joseph Gordon-Levitt and Zooey Deschanel, managed to bring in $837,588 from just 27 locations in the top 10 markets.

Ice Age: Dawn of the Dinosaurs held its own against the boy wizard at the No. 2 slot, grossing another $17.5 million. Transformers: Revenge of the Fallen held at No. 3 with $13.8 million.

Check out more of this summer's must-see movies

Universal's cringe-comedy Brüno took a dive in its second weekend, tumbling 73 percent to No. 4 for an estimated $8.3 million, for a 10-day total of $49.6 million (far below Sacha Baron Cohen's previous mockumentary, Borat, which ultimately earned $128 million).

Rounding out the top 10 were: The Hangover (No. 5, $8.32 million), The Proposal (No. 6, $8.3 million), Public Enemies (No. 7, $7.6 million), Up (No. 8, $3.1 million), My Sister's Keeper (No. 9, $2.8 million) and I Love You, Beth Cooper (No. 10, $2.7 million).